Elyasi, MiladÖzener, Okan ÖrsanYanıkoğlu, İhsanEkici, AliDolgui, A.2024-01-262024-01-2620230020-7543http://hdl.handle.net/10679/9103https://doi.org/10.1080/00207543.2023.2288866Managing blood donations is a challenging problem due to the perishability of blood, limited donor pool, deferral time restrictions, and demand uncertainty. The problem addressed here combines two important aspects of blood supply chain management: the inventory control of blood products and the donation schedule. We propose a stochastic scenario-based reformulation of the blood donation management problem that adopts multicomponent apheresis and utilises donor pool segmentation into here-and-now and wait-and-see donors. We propose a flexible donation scheme that is resilient against demand uncertainty. This scheme enables more flexible donation schedules because wait-and-see donors may adjust their donation schedules according to the realised values of demand over time. We propose a column generation-based approach to solve the associated multi-stage stochastic donation tailoring problem. The numerical results show the effectiveness of the proposed optimisation model, which provides solutions with less than a 7% optimality gap on average with respect to a lower bound. It also improves the operational cost of the standard donation scheme that does not use wait-and-see donors by more than 18% on average. Utilising multicomponent apheresis and flexible wait-and-see donations are suggested for donation organisations because they yield significant cost reductions and resilient donation schedules.engrestrictedAccessarticle00115390340000110.1080/00207543.2023.2288866Blood supply chainColumn generationMulticomponent apheresisSDG 3Good health and well-beingStochastic methods2-s2.0-85178448684