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An in-silico corrosion model for biomedical applications for coupling with in-vitro biocompatibility tests for estimation of long-term effects

dc.contributor.authorŠušteršič, T.
dc.contributor.authorŞimsek, Görkem Muttalip
dc.contributor.authorYapıcı, Güney Güven
dc.contributor.authorNikolić, M.
dc.contributor.authorVulović, R.
dc.contributor.authorFilipovic, N.
dc.contributor.authorVrana, N. E.
dc.contributor.departmentMechanical Engineering
dc.contributor.ozuauthorYAPICI, Güney Güven
dc.contributor.ozugradstudentŞimsek, Görkem Muttalip
dc.date.accessioned2023-04-27T13:34:28Z
dc.date.available2023-04-27T13:34:28Z
dc.date.issued2021-09-07
dc.description.abstractThe release of metal particles and ions due to wear and corrosion is one of the main underlying reasons for the long-term complications of implantable metallic implants. The rather short-term focus of the established in-vitro biocompatibility tests cannot take into account such effects. Corrosion behavior of metallic implants mostly investigated in in-vitro body-like environments for long time periods and their coupling with long-term in-vitro experiments are not practical. Mathematical modeling and modeling the corrosion mechanisms of metals and alloys is receiving a considerable attention to make predictions in particular for long term applications by decreasing the required experimental duration. By using such in-silico approaches, the corrosion conditions for later stages can be mimicked immediately in in-vitro experiments. For this end, we have developed a mathematical model for multi-pit corrosion based on Cellular Automata (CA). The model consists of two sub-models, corrosion initialization and corrosion progression, each driven by a set of rules. The model takes into account several environmental factors (pH, temperature, potential difference, etc.), as well as stochastic component, present in phenomena such as corrosion. The selection of NiTi was based on the risk of Ni release from the implant surface as it leads to immune reactions. We have also performed experiments with Nickel Titanium (NiTi) shape memory alloys. The images both from simulation and experiments can be analyzed using a set of statistical methods, also investigated in this paper (mean corrosion, standard deviation, entropy etc.). For more widespread implementation, both simulation model, as well as analysis of output images are implemented as a web tool. Described methodology could be applied to any metal provided that the parameters for the model are available. Such tool can help biomedical researchers to test their new metallic implant systems at different time points with respect to ion release and corrosion and couple the obtained information directly with in-vitro tests.en_US
dc.description.sponsorshipMinistry of Education, Science & Technological Development, Serbia ; European Union’s Horizon 2020 ; Ozyegin University
dc.description.versionPublisher versionen_US
dc.identifier.doi10.3389/fbioe.2021.718026en_US
dc.identifier.issn2296-4185en_US
dc.identifier.scopus2-s2.0-85115424492
dc.identifier.urihttp://hdl.handle.net/10679/8158
dc.identifier.urihttps://doi.org/10.3389/fbioe.2021.718026
dc.identifier.volume9en_US
dc.identifier.wos000697308300001
dc.peerreviewedyesen_US
dc.publicationstatusPublisheden_US
dc.publisherFrontiers Mediaen_US
dc.relationinfo:eu-repo/grantAgreement/EC/H2020/760921
dc.relation.ispartofFrontiers in Bioengineering and Biotechnology
dc.relation.publicationcategoryInternational Refereed Journal
dc.rightsopenAccess
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subject.keywordsBiomaterial corrosionen_US
dc.subject.keywordsCellular automataen_US
dc.subject.keywordsImplant surfacesen_US
dc.subject.keywordsIn silico modellingen_US
dc.subject.keywordsNickel titanium alloyen_US
dc.subject.keywordsNumerical simulationsen_US
dc.titleAn in-silico corrosion model for biomedical applications for coupling with in-vitro biocompatibility tests for estimation of long-term effectsen_US
dc.typearticleen_US
dspace.entity.typePublication
relation.isOrgUnitOfPublicationdaa77406-1417-4308-b110-2625bf3b3dd7
relation.isOrgUnitOfPublication.latestForDiscoverydaa77406-1417-4308-b110-2625bf3b3dd7

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