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dc.contributor.authorAsif, Afia
dc.contributor.authorKhawaldeh, S.
dc.contributor.authorKhan, Muhammad Salman
dc.contributor.authorTekin, Ahmet
dc.date.accessioned2020-05-26T19:32:18Z
dc.date.available2020-05-26T19:32:18Z
dc.date.issued2018
dc.identifier.issn18915469en_US
dc.identifier.urihttp://hdl.handle.net/10679/6592
dc.identifier.urihttps://content.sciendo.com/view/journals/joeb/9/1/article-p10.xml?language=en
dc.description.abstractAlthough liquid-liquid extraction methods are currently being applied in many areas such as analytical chemistry, biochemical engineering, biochemistry, and biological applications, accessibility and usability of microfluidics in practical daily life fields are still bounded. Suspended microfluidic devices have the potential to lessen the obstacles, but the absence of robust design rules have hampered their usage. The primary objective of this work is to design and fabricate a microfluidic device to quantitatively monitor the drug uptake of cancer cells. Liquid-liquid extraction is used to quantify the drug uptake. In this research work, designs and simulations of two different microfluidic devices for carrying out multiplex solution experiments are proposed to test their efficiency. These simplified miniaturized chips would serve as suspended microfluidic metabolites extraction platform as it allows extracting the metabolites produced from the cancer cells as a result of applying a specific drug type for a certain period of time. These devices would be fabricated by making polydimethylsiloxane (PDMS) molds from the negative master mold using soft lithography. Furthermore, it can leverage to provide versatile functionalities like high throughput screening, cancer cell invasions, protein purification, and small molecules extractions. As per previous studies, PDMS has been depicting better stability with various solvents and has proved to be a reliable and cost effective material to be used for fabrication, though the sensitivity of the chip would be analyzed by cross contamination and of solvents within the channels of device.en_US
dc.language.isoengen_US
dc.publisherSciendoen_US
dc.relation.ispartofJournal of Electrical Bioimpedance
dc.rightsopenAccess
dc.titleDesign and simulation of microfluidic device for metabolite screening and quantitative monitoring of drug uptake in cancer cellsen_US
dc.typeArticleen_US
dc.description.versionPublisher versionen_US
dc.peerreviewedyesen_US
dc.publicationstatusPublisheden_US
dc.contributor.departmentÖzyeğin University
dc.contributor.authorID(ORCID & YÖK ID 143103) Tekin, Ahmet
dc.contributor.ozuauthorTekin, Ahmet
dc.identifier.volume9en_US
dc.identifier.issue1en_US
dc.identifier.startpage10en_US
dc.identifier.endpage16en_US
dc.identifier.doi10.2478/joeb-2018-0003en_US
dc.subject.keywordsMicrofluidicsen_US
dc.subject.keywordsMicro and nano fabricationen_US
dc.subject.keywordsPhotolithographyen_US
dc.subject.keywordsDrug uptakeen_US
dc.subject.keywordsCancer cellsen_US
dc.subject.keywordsMultiphysics simulationen_US
dc.subject.keywordsIn vitroen_US
dc.subject.keywordsMetabolite screeningen_US
dc.identifier.scopusSCOPUS:2-s2.0-85068713318
dc.contributor.ozugradstudentAsif, Afia
dc.contributor.ozugradstudentKhan, Muhammad Salman
dc.contributor.authorMale2
dc.contributor.authorFemale1
dc.relation.publicationcategoryArticle - International Refereed Journal - Institution Academic Staff and Graduate Student


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