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dc.contributor.authorKahraman, E.
dc.contributor.authorKaragöz, Ayşe
dc.contributor.authorDinçer, S.
dc.contributor.authorÖzsoy, Y.
dc.date.accessioned2016-06-29T13:04:24Z
dc.date.available2016-06-29T13:04:24Z
dc.date.issued2015
dc.identifier.issn1550-7041
dc.identifier.urihttp://hdl.handle.net/10679/4060
dc.identifier.urihttp://www.ingentaconnect.com/content/asp/jbn/2015/00000011/00000005/art00012?token=003915a0ba472573d257025706a23446c5f316a59386b637c4e724725
dc.descriptionDue to copyright restrictions, the access to the full text of this article is only available via subscription.
dc.description.abstractThis study evaluates the ability of polyethylenimine-modified and non-modified polymeric micelles to enhance permeation through the nasal mucosa for a highly hydrophobic model drug. Carvedilol was loaded into polyethylenimine-modified and non-modified micelles by direct dissolution. Formulations were characterised by critical micelle concentration, micelle particle size and distribution, zeta potential, morphological structure and entrapment efficiency. The drug entrapment efficiency was determined to be as high as 77.14%, while micelle particle sizes and zeta potentials were within the range of 140.0-279.9 nm and (-40.6)-(+25.9) mV, respectively. In vitro studies showed 100% release of carvedilol from micelles in 120 hours. Ex vivo permeation studies showed that the drug in polyethylenimine non-modified micelles passed more efficiently than the drug in polyethylenimine modified micelles. These results demonstrated that polyethylenimine modified micelles did not significantly affect the permeation of the drug when compared to polyethylenimine non-modified micelles. On the contrary, the drug in poly(L-lactide)-block-methoxy poly(ethylene glycol) 5000 micelles, the polyethylenimine non-modified micelles, showed the highest permeation rate through bovine nasal mucosa. In conclusion, poly(L-lactide)-block-methoxy poly(ethylene glycol) 5000 polymeric micelles maybe useful as novel drug carriers that increase the permeation through the nasal mucosa.
dc.description.sponsorshipResearch Fund of Istanbul University
dc.language.isoengen_US
dc.publisherAmerican Scientific Publishers
dc.relation.ispartofJournal of Biomedical Nanotechnology
dc.rightsrestrictedAccess
dc.titlePolyethylenimine modified and non-modified polymeric micelles used for nasal administration of carvedilolen_US
dc.typeArticleen_US
dc.peerreviewedyes
dc.publicationstatuspublisheden_US
dc.contributor.departmentÖzyeğin University
dc.identifier.volume11
dc.identifier.issue5
dc.identifier.startpage890
dc.identifier.endpage899
dc.identifier.wosWOS:000344969800012
dc.identifier.doi10.1166/jbn.2015.1915
dc.subject.keywordsPolymeric micelle
dc.subject.keywordsNasal permeation
dc.subject.keywordsPolyethylenimine (PEI)
dc.subject.keywordsPoly(L-lactide)-block-methoxy poly(ethylene glycol)5000 (PLL-b-mPEG5000) micelles
dc.subject.keywordsCarvedilol
dc.identifier.scopusSCOPUS:2-s2.0-84918532923
dc.contributor.ozugradstudentKaragöz, Ayşe
dc.contributor.authorFemale1


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