LoC sensor array platform for real-time coagulation measurements
Author
Type :
Conference paper
Publication Status :
published
Access :
restrictedAccess
Abstract
This paper reports a MEMS-based sensor array enabling multiple clot-time tests in one disposable microfluidic cartridge using plasma. The versatile LoC (Lab-on-Chip) platform technology is demonstrated here for real-time coagulation tests (activated Partial Thrompoblastin Time (aPTT) and Prothrombin Time (PT)). The system has a reader unit and a disposable cartridge. The reader has no electrical connections to the cartridge, which consists of multiple microfluidic channels and MEMS microcantilevers placed in each channel. Microcantilevers are made of electro-plated nickel and actuated remotely using an external electro-coil. The read-out is also conducted remotely by a laser and the phase of the MEMS oscillator is monitored real-time. The system is capable of monitoring coagulation time with a precision estimated at 0.1sec.
Source :
2014 IEEE 27th International Conference on Micro Electro Mechanical Systems (MEMS)
Date :
2014
Publisher :
IEEE
URI
http://hdl.handle.net/10679/2530http://ieeexplore.ieee.org/xpl/articleDetails.jsp?reload=true&arnumber=6765643
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